Futurismic

Genetically engineered bacteria have been used to deliver therapies for bowel disorders like inflammatory bowel disease:

The bacterium is able to deliver the protein, a human growth factor called KGF-2, directly to the damaged cells that line the gut, unlike other treatments which can cause unwanted side effects. Also unlike other treatments, it is envisaged that patients will be able to control the medication themselves by ingesting xylan, perhaps in the form of a drink.

I am not 1 of the 400 Britons who suffers from IBD but it is wonderful to see that genetic engineering has such excellent medical applications.

[from Science Daily][image from Deco Fernandez on flickr]

The image of the appendix has been getting a makeover. Two years ago, Duke U. researchers suggested it is not the useless evolutionary vestige that Darwin said it was.

The appendix, they said, is a safe haven where good bacteria could hang out until they were needed to repopulate the gut after a nasty case of diarrhea, for example.

Now some of the team suggest the appendix has been around a lot longer than Darwin thought.

[Surgical sciences professor William] Parker and colleagues found that the appendix has evolved at least twice, once among Australian marsupials and another time among rats, lemmings and other rodents, selected primates and humans. “We also figure that the appendix has been around for at least 80 million years, much longer than we would estimate if Darwin’s ideas about the appendix were correct.”

Parker says Darwin just didn’t have access to enough information about the organ.

“If he had known about the widespread nature of the appendix, he probably would not have thought of the appendix as a vestige of evolution.”

He also was not aware that appendicitis, or inflammation of the appendix, is not due to a faulty appendix, but rather due to cultural changes associated with industrialized society and improved sanitation. “Those changes left our immune systems with too little work and too much time their hands – a recipe for trouble,” says Parker.

[Story tip: Phoenix New Times blog; CT image by jellywatson]

Still looking for new niche magazine publishing strategies? I sure am – and here’s one that doesn’t revolve around free web content. Indeed, someone’s starting a high quality print magazine on a subscription model. Ladies and gentlemen, we give you World Of Warcraft: The Magazine. Take it away, Ars Technica:

Clearly, there is much to be skeptical about, but the team behind the magazine makes a strong case for a publication of this type. Here’s the scoop on how they plan to sidestep the issues of traditional magazine publishing and still make a profit.

“This won’t be driven by advertising; it’s based on a print-on-demand format. We will launch the subscription website on Friday, monitoring who is subscribing in what language, and print that many copies exactly,” John Gower, International Director of FuturePlus, told Ars. “This will be environmentally friendly—no waste.” This print on demand format allows them to keep publishing costs as low as possible, and releasing magazines to subscribers only—no newsstand—will make sure no copies get thrown away.

“I’m not sure gamers were walking into Waldenbooks to find the newest information anyway,” Dan Amrich, the magazine’s editor in chief, said. So how will the quarterly magazine be advertised? The magazine will launch at Blizzcon, with people being able to subscribe for $39.95, £29.95, or €34.95. That may seem high for four issues a year, but the team is promising a high-quality, large format magazine with heavy paper stock, a glossy cover, and 148 pages an issue… and no ads. “We want this to be a nice surprise when people get it in the post, like unwrapping a Christmas present every quarter.”

Now, the advantage WoW:TM has here over a more general magazine is a ready-made niche interest base of considerable size to pitch to, plus direct access to the information and content that that niche is going to want. But they’re also treating the readers with respect by removing the crappy ads that seem to fill more than half of most game or tech mags, and aiming for a quality physical product that you’re going to want to keep; I’m assuming the content will lean towards stuff that isn’t too time-sensitive. Furthermore, they save on the dreaded pulping margin by going with print-on-demand, keeping their overheads low.

So, I see two takeaways here for the genre fiction scene in particular. First of all, is this a potential model for the genre fiction print magazine surviving? We’ve talked POD in genre before, but I don’t remember it being combined with the no-ads idea. A magazine that makes the effort to be an artefact, a thing of beauty – I’m thinking more Interzone than Asimov’s on the aesthetic front, here – while also delivering 100% great content for a reasonable price… well, in some respects this isn’t that different a model to the existing one, at least in some cases. If WoW:TM succeeds, what will that say about the viability of genre magazines? Is the death of print simply a question of costs not scaling?

Secondly, and maybe more pertinently: World Of Warcraft: The Magazine strikes me as a damn good market for fantasy writers to pitch stories to.

Earlier this year I mentioned round-the-clock in-body medical monitoring as an imminent transhuman reality, but I didn’t think it’d be quite so fast.

OK, so it’s not a full suite of biomonitors, but a new design of pacemaker talks wirelessly to an internet-connected basestation in the home, sending all the data it gathers directly to the outpatient’s doctor:

So, basically, this patient can provide a full report on the condition of her heart without even leaving home – without doing anything, actually, since the pacemaker reports automatically – and the doctor is able to perform regular check-ups without seeing the patient at all. In fact, since routine pacemaker checks are typically done every six months, the wireless device offers a much greater level of monitoring and care than ever before.

The logical next step here is to make the basestation into some kind of expert system that can deal with routine changes of circumstance without having to involve a busy meat-doctor. Perhaps next time there’s a global epidemic we’ll just be able to breathe into a little device and have it tell us whether we have swine flu or a bit of a cold, followed by advice on how to respond to it. [image found via koreana]

Via Futurismic‘s long-term good buddy Mac Tonnies come the results of an analysis of the UK MoD’s “x-files” documents, recently released to public scrutiny; apparently UFO sightings were more common around the times at which popular films or television shows featuring alien races or spacecraft were screened. [image by eek the cat]

The obvious conclusion here is “well, skiffy movies cause alien sightings; case closed”. But as Mac points out, that’s not logically sound:

There’s doubtlessly a correlation between science fiction and UFO reports. But while pop culture’s influence on potential UFO observers is a fascinating subject with important sociological ramifications, to flaunt Clarke’s findings as a refutation of the phenomenon in general is to willfully ignore the evidence in its entirety.

UFO researchers aren’t interested in “noise” cases — the inevitable false alarms that plague efforts to study the phenomenon (whatever its origin). Indeed, scientists who have addressed the UFO problem have always been painfully aware of the disproportionately high volume of false returns.

Now, you may more skeptical than Mac regarding the causes of UFO sightings, but his point still stands – divorce the logic from the specific subject matter, and the same applies to any sort of genuine scientific enquiry. I’m pretty sure this is what they call confirmation bias at work, and it makes me wonder how often it affects us…

… although it obviously happens often enough for it to be politically useful.