Viruses used to kill cancer cells

tamedviruswiA fascinating concept: researchers at the University of Oxford have developed a method that uses modified viruses to destroy cancerous cells, whilst leaving healthy cells intact:

The research team modified a common virus – called an adenovirus – so that it could deliver genetic therapy to destroy tumours without poisoning the liver.

The changes enabled the virus to keeps its natural ‘infectious’ characteristics to replicate in, and kill, cancer cells in mice.

But for the first time the virus is also recognised and destroyed by healthy mouse liver cells, so it is no longer toxic.

Poachers make the best gamekeepers, no?

[from Physorg][image from Physorg]

Friday Free Fiction for 22nd May

It’s Friday again… and unless I’m mistaken, this is one of those weekends where folk on both sides of the pond have a Monday off. Which is reason to be cheerful – so why not celebrate by reading some free science fiction stories online, eh? C’mon, your boss is probably coasting his way to close-of-business anyway, who’s gonna notice? Step this way…

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Here’s a bunch from ManyBooks:

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And a couple from FeedBooks:

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Jason Stoddard‘s Creative Commons release of Eternal Franchise continues; we’re up to chapter 8.1

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Yet another Shadow Unit Season 2 DVD Extra: “The Truth

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News from Arkham Tales:

Issue #3 of Arkham Tales is now available for free download! This issue features a cover by George Cotronis, and contains fiction by Nicholas Ozment, J.C. Koch, Rob Brooks, Nandi Ekles, Eric W. Jepson, Maura McHugh, J.J. Beazley and Edward Morris.

Their server seems a little flaky at the moment (possibly just overloaded on release day) so give the refresh button a few jabs if you get a connection error.

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I’m not sure if it’s entirely meant to be read as fiction, but Ken MacLeod‘s “Invasion Dream” is a pretty weird read nonetheless.

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HUB Magazine #87 features “Nightlife” by Dean Grondo

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Here’s Memory part 37 by Jayme Lynn Blaschke

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The SF Signal gang have made my life a little easier with a couple of free fiction link posts. Meanwhile, here’s another few snippets that passed through there over the week:

  • The latest issue of Three Crow Press includes fiction by Catherine Knutsson, Glenn Lewis Gillette, T A  Moore, C M  SheVLin, Nu Yang, Brian Dolton, Shannon Page and Jay Lake, Gary McMahon, David Priebe, and Rick Silva
  • Conjunctions presents “Predecessor” by Jeff VanderMeer; looks like they have more free fiction over there, too, but a distinct lack of RSS feed.

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And to close us up, Sumit Dam sneaks in with “Lives of Quiet Desperation“.

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And that’s all, folks, as the cartoon pig used to say. Don’t forget to drop us a line if there’s something you think we should collect here next week, but more importantly, have the best weekend you can, OK? Peace…

Cellphone epidemiology- Japan’s swine flu panopticon

mother, child and cellphoneIn response to the swine flu almost-epidemic, my government thoughtfully sent me a leaflet, advising me to steer clear of people sneezing and so on. The Japanese Ministry of Internal Affairs and Communications, however, appears to be approaching the problem from a more technological angle; this autumn, they’ll test a system that uses mobile phones to track the locations of citizens and inform them whether they’ve been in contact with a flu carrier:

The proposed system relies on mobile phone providers to constantly track the subjects’ geographical locations and keep chronological records of their movements in a database. When a person is labeled as “infected,” all the past location data in the database is analyzed to determine whether or not anyone came within close proximity to the infected individual.

The system will know, for example, whether or not you once boarded the same train or sat in the same movie theater as the infected individual, and it will send you a text message containing the details of the close encounter. The text messages will also provide instructions on specific measures to take in response.

The primary purpose of the test, which will involve about 2,000 volunteers in both urban and rural areas, is to verify the precision of GPS tracking technology, estimate the potential costs of operating such a system, and determine whether or not such a system can be put into practical use.

The first problem that leaps to mind here is that just one or two undiagnosed flu carriers loose in your city is going to throw a spanner in the works; those few errors will multiply exponentially over time.

Secondly – and channelling my tin-foil hat-wearing younger self for a moment – what a fantastically comprehensive way to monitor and control your population, should you decide you need (or want) to, and what a great excuse to coat the pill with. There’s a polical-dystopian technothriller just waiting to be written right there; just replace the word ‘infected’ with ‘subversive’ in the above quotes, and off you go. [via Technovelgy; image by kalandrakas]

Big Food: What to do about hypereating

lolHere’s an optimistic vision of the future, from the last page of The End of Overeating by former US Food & Drug Administration commissioner David A. Kessler, MD (available here and elsewhere; reviewed here; author interview by Stephen Colbert here.)

A change in perspective cannot be imposed with mandates, but must evolve as a social consensus. The goal is not to vilify all food and those who serve it, but to change our thinking about big food, those huge portions of layered and loaded food with little nutritional value. We need to look differently at the people and the places that serve it. When their power to manipulate our behavior becomes fully transparent, cues will lose their capacity to entice. Instead of expecting food to be served at every social and business occasion, we’ll realize that many offers of food outside mealtimes do not serve anyone’s interest.

In the future, new social norms and values will emerge, and food choices, offered in smaller portion sizes, will seem ‘right’ to us. That will be what we come to expect, and that will be what we want.

So, yes, as research for my optimstic sf story, I broke down, bought, and read this book, which is short, readable, and provocative.

Kessler’s thesis is that since the 80s, millions of Americans have been on a binge of conditioned hypereating, brought about by a food industry that knows how to get people to keep chowing down even when they’ve eaten more than enough. They do it with marketing, focus grouping, advertising, and even such childishly simple methods as making food easier to chew and swallow.

Kessler cites enough neuroscience data from human and animal experiments to put together a working hypothesis of marketing-driven food addiction. Among other things, the industry excels at creating tastes, textures, situations, and associations that rewire the brain to want more and more of certain kinds of foods. For example,

…[A]n animal that eats a combination of sucrose, chocolate, and alcohol releases the greatest levels of dopamine [a brain chemical associated with “attentional bias.”].

Not surprisingly, these foods have layers of sugar, salt, and fats — often in repeating geological layers. It’s akin to the tobacco industry’s striving to make cigarettes even more addictive. The food merchants seem to accomplish their goals more by trial and error than through pure research, but the result is plain for all to see: A serious obesity problem with, at the very least, a larger health care bill attached.

People need to take responsibility, and Kessler lays out some steps that will probably spawn a lot of self-help books (some of us can use the help). He simply asks that people watch how they feel when exposed to food or come-ons to the same, and alter their behavior accordingly. And maybe do what the French, he says, do, or at least used to do: Take your time at the table, and don’t eat between meals. Old-fashioned, and easier said than done.

He has policy suggestions, too. Some of them ought to be adopted for the sheer entertainment value of the outrage and resistance they’re likely to provoke.

  • Restaurants should list calorie counts, “by mandate, if they’re not willing to do so voluntarily.
  • Food package labels should contain percentages of added sugars, refined carbs, and fats.
  • Public education should focus a jaundiced eye on “big food.”
  • And my personal favorite: Marketing should be monitored and exposed.

Our greatest gift to future generations … would be to find a way to prevent the cue-urge-reward-habit cycle from ever taking hold.

There’s optimism for you. And there’s got to be some way to turn this into a story.

[I Can Haz Cheezburger?, due to sheer lack of willpower]