Category Archives: Blog

To sleep, perchance to dream…

labmice A long-time staple of science fiction has been the concept of suspended animation. It’s one of the ways to get around the immensely long travel times astronauts heading to the outer planets or other solar systems must endure. The usual SFnal approach has been “cold sleep,” where the suspended animation is achieved by means of extremely low temperatures: a kind of cryogenic suspension, with undefined futuristic technology somehow prevent cell damage and death in the human icicles.

Turns out, there just might be another way: low doses of hydrogen sulfide, the stinky gas that is responsible for the unpleasant odor of rotten eggs, and which is fatal in large doses, can, in small, controlled doses, safely and reversibly depress both metabolism and cardiovascular function in mice, producing a suspended-animation  like state (Via EurekAlert):

In all the mice, metabolic measurements such as consumption of oxygen and production of carbon dioxide dropped in as little as 10 minutes after they began inhaling hydrogen sulfide, remained low as long as the gas was administered, and returned to normal within 30 minutes of the resumption of a normal air supply. The animals’ heart rate dropped nearly 50 percent during hydrogen sulfide adminstration, but there was no significant change in blood pressure or the strength of the heart beat. While respiration rate also decreased, there were no changes in blood oxygen levels, suggesting that vital organs were not at risk of oxygen starvation.

Of course, it’s always a large and fraught step from mice to humans, but if this discovery is transferable to humans, it could be used to allow organ function to be preserved when oxygen supply is limited, such as after a traumatic injury, the researchers say. the next step will be to study the use of hydrogen sulfide in larger mammals. It’s possible, they say, that in larger mammals hydrogen sulfide could be delivered via intravenous drugs, which would prevent lung toxicity.

Warren Zapol, MD, the chief of Anesthesia and Critical Care at Massachusetts General Hospital and senior author of the study, sums it up: “This is as close to instant suspended animation as you can get, and the preservation of cardiac contraction, blood pressure and organ perfusion is remarkable.”

Start booking those flights to Alpha Centauri!

(Image: Wikimedia Commons)

[tags]medicine, suspended animation, mice, space travel[/tags]

Stem Cells show major breakthrough in treatment of Parkinson’s

Is this a cure or should we leave it alone?The UK parliament this week is considering a wide-reaching bill on stem-cell research. Under pressure from a number of religious groups, Prime Minister Gordon Brown has allowed MPs to have a ‘free vote’ on certain parts of the bill. There’s no doubt that stem cells are a tricky moral issue – are they to be considered alive, or just a group of cells like a skin transfusion?

Meanwhile, a study of stem cell use has shown that they can make a great deal of impact in reversing the effects and possibly curing Parkinson’s disease. Other degenerative diseases such as Alzheimers are also thought to be potentially cured by treatment with stem cells. The big advantage to this latest scientific discovery is that the mice in the study did not reject the stem cells, a major step forward in the useability of the treatment.

To be sure the issue is a very complex one. Is it better to not play around with cells taken from embryos, even those that would only be disposed of? Is it a can of worms best left alone or are the moral quandaries worth it for the difference that could be made to the many people with diseases stem cells are thought to help? It’s a difficult choice but one we’ll have to face in the coming decades. Scientists are making great advances in the field and sooner or later will produce cures for some diseases. We’ll have to choose whether it’s right to use them or not.

[picture via BBC]

Moving the Earth

450825428_b0ef55b12e_m_d The typical ending of our lovely planet will come in several billion years when the Sun swells up and engulfs all of the inner planets.  But it’s never too early to start thinking of how to rescue our beloved cradle.

According to an article in the NYTimes, the Earth faces an unknown future because it will move further out in orbit as the Sun expends its mass and the gravitational forces become weaker.

One solution is to lasso comets and asteroids, swinging them near the Earth and using their slight gravity to boost the Earth to a higher orbit, where it could escape the Sun’s expansion.  Because, y’know, what could go wrong with that?

(image from NASA website)

Voice-activated remote control – the apogee of laziness

ApriPoko remote control robot While it’s generally becoming more accepted that exercise is a good thing that we should all do more of, the good folk at Toshiba are still designing with the couch potato very much in mind.

This typically Japanese-cute and anthropomorphic little fellow is ApriPoko, a household robot who learns the commands that your remote controls make so you can trigger them by talking to him:

“ApriPoko sits in the living room and waits for you to use a remote control. When its sensors detect infrared rays emitted by a remote, the robot speaks up: “What did you just do?” it asks. Tell ApriPoko what you did (”I turned on the stereo” or “I changed to channel 321,” for example), and it commits the details to memory. Then, next time you want to turn on the stereo or change the channel, simply tell ApriPoko and it transmits the appropriate IR signal directly to the device.”

We may not have our long-promised robot butlers yet, but ApriPoko should at least take on the duties that most of us relied on our younger siblings to perform … [image lifted from linked Pink Tentacle article]