Space race rebooted? Or, y’know, not.

All this talk of rocketry and path dependency, and now it looks like we’re going to re-run one of the classic (arguably) bloodless megaconflicts of the 20th Century all over again: Russia is working on a clone-job of the US Air Force’s little-known but oft-alluded-to “spaceplane”, the X-37B Orbital Test Vehicle!

Stepping away from sensationalist overstatement for a moment (hey, us internet hacks have to attract eyeballs somehow, right?), I don’t think this is anywhere near as big a story as it it’s being made out to be. For a start, all we have to go one regarding the Russian project is a statement of intent, and given the state of the Russian economy (and the alleged state of its government), I’m not sure they’re in any position to pour funding and expertise into a space race right now… indeed, I’d have thought China would be a more potent potential player on that particular gameboard.

Secondly, a similar but less severe problem pertains with the United States, namely the same econopolitical instability that’s so globally fashionable right now (“favela chic, darling – everyone‘s doing it!”). I don’t doubt there’s work being done on the X-37B, but I can’t see it being a significant budget draw in an era of domestic financial woes, long drawn-out “liberation” projects in the Middle East, and an internecine state of polarised political pugilism.

Again, among the nation-state players I’d say China looks like a much better bet for significant progress toward the top of the gravity well in the next decade or so. The commercial space outfits may make some strides as well, but given the sort of characters heading those organisations, I suspect any allegience to the U.S. as anything other than a source of expertise and skills will be more a matter of convenince and expedience than of national pride.

Nonetheless (and as I seem to be saying on a pretty much daily basis of late), interesting times ahead.

Interactive fractal maps

Perhaps bored with mapping real places, Google turns to the mathematical landscapes of fractal equations with JuliaMaps – all the fun of generative fractals without any of the need for downloading software (sorry, Rudy Rucker). So if you feel the need for a short dose of visual psychedelia during your lunchbreak, you’re all sorted. Turn out the lights, will you?

EDIT: I’ve not tried it with the Big G’s own Chrome, but Firefox and Opera are both really struggling to handle JuliaMaps right now – it works, but it’s mad slow. Rucker’s software might be a better bet after all! 🙂

Biopharming: transgenic animals as medicine-factories

That sound you can hear is sound of bioconservatives gnashing their teeth in horror: COSMOS Magazine has a decent long piece on transgenic animals and the role they may play in tomorrow’s pharmacology:

The greatest impact biopharming will have on the world’s medicine cabinet is one of supply – it will dramatically boost the availability of biopharmaceuticals, also known as ‘biologics’. Biologics are defined as medicinal products extracted from or produced by biological systems – many are made by genetically manipulating cells of bacterial, animal or human origin.

The majority of biologics are proteins such as hormones, enzymes, growth factors and antibodies, which can be collectively called therapeutic proteins, as well as viral proteins for use in vaccines.

This method of drug manufacture will make things cheaper… but not to the degree that you might expect:

A review of the scientific literature shows that a slew of antibody-based drugs manufactured in transgenic animals are poised to enter the market as soon as their branded competitors’ patents expire.

Traditionally, this would result in the transgenic animal-manufactured drugs being labelled as generic drugs – a non-patented, cheaper alternative to brand-name medications with the same active ingredient.

But because the antibodies that the transgenic animals produce are extremely complex monoclonal antibodies – large protein-based structures that specifically recognise one part of a target molecule – no two are alike. This means that, unlike the less complex ‘small molecule’ (non protein) structure of most drugs, they cannot technically be called generics.

“When GTC Biotherapeutics start marketing Herceptin from transgenic cows, it will be classed as a biosimilar, not a biogeneric. We may even end up having a better Herceptin, what we’d call a ‘biobetter’,” notes Heiden.

The ‘better’ refers to aspects of a drug’s profile that may be more desirable than those of its competitor, such as better efficacy or fewer side effects. These traits will affect pricing, but biosimilars will still be cheaper.

“The cost savings will be in the order of 30% – not the 80% price drops we see when a generic small molecule drug goes to market,” says Heiden. That’s because of where in the manufacturing process the savings impact. “Where we save money is at the front end. But the downstream cost of goods, which is about half of the total, is the same regardless of whether you are using cell culture or animals on a farm. You still have to extract and purify your product.”

Well, you do if you’re playing by the rules… I’ll bet there’s plenty of corners that can be cut if you’re not too bothered about meeting safety standards. Hmmm, the ideas for my genetic police procedural are all falling rapidly into place…

Path dependency: why we still use rockets

Very interesting piece by ubergeek Neal Stephenson over at Slate, where he wonders why it is that we’re still stuck in the rocket paradigm of space launch tech. In two words: path dependency.

To recap, the existence of rockets big enough to hurl significant payloads into orbit was contingent on the following radically improbable series of events:

1. World’s most technically advanced nation under absolute control of superweapon-obsessed madman

2. Astonishing advent of atomic bombs at exactly the same time

3. A second great power dominated by secretive, superweapon-obsessed dictator

4. Nuclear/strategic calculus militating in favor of ICBMs as delivery system

5. Geographic situation of adversaries necessitating that ICBMs must have near-orbital capability

6. Manned space exploration as propaganda competition, unmoored from realistic cost/benefit discipline

The above circumstances provide a remarkable example of path dependency. Had these contingencies not obtained, rockets with orbital capability would not have been developed so soon, and when modern societies became interested in launching things into space they might have looked for completely different ways of doing so.

Before dismissing the above story as an aberration, consider that the modern petroleum industry is a direct outgrowth of the practice of going out in wooden, wind-driven ships to hunt sperm whales with hand-hurled spears and then boiling their heads to make lamp fuel.

It’s this sort of thinking that makes Stephenson’s novels so fascinating to me… and, I fully expect, what makes other people bounce right off them. To Stephenson, everything is a system, and a system is a sort of story. Or maybe it’s the other way around? Anyway, the point is that for all our talk – and worship – of innovation, we’re mired in a whole interconnected set of path dependencies, a kind of civilisational stasis where we don’t do amazing new things so much as we find new ways to do the same things we’ve always done, only bigger, faster and with greater consequences of failure.

… the endless BP oil spill of 2010 highlighted any number of ways in which the phenomena of path dependency and lock-in have trapped our energy industry on a hilltop from which we can gaze longingly across not-so-deep valleys to much higher and sunnier peaks in the not-so-great distance. Those are places we need to go if we are not to end up as the Ottoman Empire of the 21st century, and yet in spite of all of the lip service that is paid to innovation in such areas, it frequently seems as though we are trapped in a collective stasis. As described above, regulation is only one culprit; at least equal blame may be placed on engineering and management culture, insurance, Congress, and even accounting practices. But those who do concern themselves with the formal regulation of “technology” might wish to worry less about possible negative effects of innovation and more about the damage being done to our environment and our prosperity by the mid-20th-century technologies that no sane and responsible person would propose today, but in which we remain trapped by mysterious and ineffable forces.

A fascinating and provocative read: go see the whole thing.

Heavy Rain: Free Will and Quick Time Events

It could have been ugly. When the French developers Quantic Dream announced that they were working on an ‘interactive film’ that used quick time events as the primary mode of player interaction you could hear the sceptical harrumphing from orbit. Many gamers compared the game to Cinematronics’ infamous laser disc-based arcade game Dragon’s Lair (1983).

Screenshot from Dragon's LairAt a time when most video games were comprised of poorly animated coloured blocks, the cartoon imagery of Dragon’s Lair was ground-breaking. Here was a game that did not simply suborn the language and titles of films; it actually looked like a film too. The only problem was that when players fed their money into the machine, they soon discovered that they didn’t actually have control over the on-screen action. Continue reading Heavy Rain: Free Will and Quick Time Events