All posts by Tom Marcinko

Sifting through the genes that make humans unique

AnimaBiologists used to think that new genes “could only evolve from duplicated or rearranged versions of preexisting genes.” Now, though:

Scientists have made a crucial discovery of genes that have evolved in humans after branching off from other primates, opening new possibilities for understanding what makes us uniquely human….

Researchers have found genes that arose from non-coding DNA in flies, , and primates. No such genes had been found to be unique to humans until now, and the discovery raises fascinating questions about how these genes might make us different from other primates….

The authors [David Knowles and Aoife McLysaght of the Smurfit Institute of Genetics at Trinity College Dublin] also note that because of the strict set of filters employed, only about 20% of human genes were amenable to analysis. Therefore they estimate there may be approximately 18 human-specific genes that have arisen from non-coding DNA during human evolution.

This discovery of novel protein-coding genes in humans is a significant finding, but raises a bigger question: What are the proteins encoded by these genes doing? “They are unlike any other human genes and have the potential to have a profound impact,” McLysaght noted. While these genes have not been characterized yet and their functions remain unknown, McLysaght added that it is tempting to speculate that human-specific genes are important for human-specific traits.

[Image: Dollar Bin]

E.O. Wilson tells Will Wright: ‘Games are the future in education’

dragonNational Public Radio just aired a wonderful conversation between Spore and Sims creator Will Wright and Harvard biologist E.O. Wilson, well worth a read or listen. But the chat didn’t go the way Wright thought it would:

I came into the interview with all these questions I wanted to ask him about evolution,” Wright said, “but his first response was, ‘Oh, I thought we were going to talk about games!'”

Wright wasn’t completely surprised. One of Wilson’s goals has been to “unify science with disciplines such as the humanities,” Wright said. “He is one of the few scientists who really has the guts to do that.”

So, asked by Wright about the role of games in education, Wilson said:

“I’ll go to an even more radical position,” Wilson said. “I think games are the future in education. We’re going through a rapid transition now. We’re about to leave print and textbooks behind.”

Wilson imagines students taking visits through the virtual world to different ecosystems. “That could be a rain forest,” he said, “a tundra — or a Jurassic forest.”

Wilson said that for the most part, we are teaching children the wrong way. According to the biologist, “When children went out in Paleolithic times, they went with adults and they learned everything they needed to learn by participating in the process.”

That’s the way the human mind is programmed to learn, Wilson said.

But he believes that today, virtual reality can be a steppingstone to the real world. It can motivate a child to exploration.

Wilson had a very different experience growing up. He explored the real world — and its creatures and plants — from a very young age. He credits his permissive parents and the schools he attended for allowing him to “disappear” into the forest.

“No one knew what I was doing,” he said.

Wilson is now studying the origins of altruistic behavior, taking his cue from Paul Gauguin: “Where did we come from? Who are we? Where are we going?” An education system that produces that kind of curiosity is the one I want for kids today.

Such ideas aren’t new to most of us, but it’s encouraging to hear them nudge their way towards conventional wisdom.

[Image: Torley]

The coldest, driest place on Earth would be a great place for an astronomical telescope

antarcticaNo human has ever set foot on Ridge A, 4,053m up the Antarctic Plateau. But a U.S.-Australian team collating satellite, ground-station, and climate-model data thinks it’s the coldest, driest place on the planet–and therefore the best place on Earth to set up an astronomical observatory.

The study revealed that Ridge A has an average winter temperature of minus 70C and that the content of the entire atmosphere there is sometimes less than the thickness of a human hair.

It is also extremely calm, which means that there is very little of the atmospheric turbulence elsewhere that makes stars appear to twinkle: “It’s so calm that there’s almost no wind or weather there at all,” says Dr Will Saunders, of the Anglo-Australian and visiting professor to UNSW, who led the study.

“The astronomical images taken at Ridge A should be at least three times sharper than at the best sites currently used by astronomers,” says Dr Saunders. “Because the sky there is so much darker and drier, it means that a modestly-sized telescope there would be as powerful as the largest telescopes anywhere else on earth.”

It’s not the first time Antarctica has been proposed as a site for stargazing:

Located within the Australian Antarctic Territory (81.5◦ S 73.5◦ E), the site is 144km from an international robotic observatory and the proposed new Chinese ‘Kunlun’ base at Dome A (80.37 S 77.53 E).

Interest in Antarctica as a site for astronomical and space observatories has accelerated since 2004 when UNSW astronomers published a paper in the journal Nature confirming that a ground-based telescope at Dome C, another Antarctic plateau site, could take images nearly as good as those from the space-based Hubble telescope.

Last year, the Anglo-Australian Observatory completed the first detailed study into the formidable practical problems of building and running the proposed optical/infra-red PILOT telescope project in Antarctica. The 2.5-metre telescope will cost over AUD$10million and is planned for construction at the French/Italian Concordia Station at Dome C by 2012.

I confess I haven’t read Kim Stanley Robinson’s novel Antarctica, but I’d be surprised if he missed this. But writers looking for a setting should find the neighborhood isn’t too crowded. Bring your mittens.

[Image: Antarctic Peninsula, giladr]

Depression may be evolution’s way of telling us to think things over

hello“Mental disorders should generally be rare,” state researchers Paul W. Andrews and J. Anderson Thomson, Jr. ” — why isn’t depression?” It doesn’t seem to be a function of aging and culture, yet prescription drugs for it help keep pharmaceutical companies afloat.

There is another possibility: that, in most instances, depression should not be thought of as a disorder at all. In an article recently published in Psychological Review, we argue that depression is in fact an adaptation, a state of mind which brings real costs, but also brings real benefits…. So what could be so useful about depression? Depressed people often think intensely about their problems. These thoughts are called ruminations; they are persistent and depressed people have difficulty thinking about anything else. Numerous studies have also shown that this thinking style is often highly analytical. They dwell on a complex problem, breaking it down into smaller components, which are considered one at a time….

Many other symptoms of depression make sense in light of the idea that analysis must be uninterrupted. The desire for social isolation, for instance, helps the depressed person avoid situations that would require thinking about other things. Similarly, the inability to derive pleasure from sex or other activities prevents the depressed person from engaging in activities that could distract him or her from the problem. Even the loss of appetite often seen in depression could be viewed as promoting analysis because chewing and other oral activity interferes with the brain’s ability to process information.

But is there any evidence that depression is useful in analyzing complex problems? For one thing, if depressive rumination were harmful, as most clinicians and researchers assume, then bouts of depression should be slower to resolve when people are given interventions that encourage rumination, such as having them write about their strongest thoughts and feelings. However, the opposite appears to be true. Several studies have found that expressive writing promotes quicker resolution of depression, and they suggest that this is because depressed people gain insight into their problems.

The idea that depression–which the authors acknowledge is painful and can be serious–can have a purpose is a new idea to me.

I’m going to go lie in a dark room and think about it.

[Image: Somebody Needs a Hug by Robyn Gallagher]

Boat-cleaning robots for a greener ocean?

autonomousunBarnacles, oysters, algae, and other sea-life can slow a ship by 10% and increase fuel consumption by as much as 40%. The U.S. Office of Naval Research is testing a Roomba-like autonomous hull-cleaning robot to cut the drag.

The robot incorporates the use of a detector that utilizes modified fluorometer technology to enable the robot to detect the difference between the clean and unclean surfaces on the hull of a ship. Used to groom ships in port, the Hull BUG [Bio-inspired Underwater Grooming tool] removes the marine biofilm and other marine organisms before they get solidly attached. This is especially important because Navy ships spend more than 50 percent of their service life in port, giving barnacles and marine life ample time to become settled and, if allowed, to further colonize and grow on the ship’s hull.

Underscoring the benefits of combining the Hull BUG with newly developed environmentally benign antifouling hull coatings, [ONR Program Officer Steve] McElvany estimates that “the Navy will save millions of dollars per year in fuel. Using less fuel also means less carbon dioxide in the atmosphere.”

[Photo: U.S. Navy]