Tag Archives: genetics

The Human Genre Project: mapping the genome with fiction

genesHere’s Ken MacLeod announcing a rather interesting science fiction project:

A while ago I was staring at a poster of the human genome produced by the US Dept of Energy, and I remembered Michael Swanwick’s Periodic Table of Science Fiction. Cue lightbulb moment.

Why not set up a website that displayed short pieces – stories, flash fictions, poems, and reflections – inspired by genes or genomics, and arranged them (as far as possible – I soon found myself applying for an artistic licence) according to the chromosome that carries the gene that inspired the piece?

[…]

Now, thanks to enthusiastic work from Emma Capewell and Claire Alexander at the Genomics Forum, and the creative skills of web designer Damien Noonan, The Human Genre Project has gone live. It’s early days yet, but it looks good and it’s just waiting to be filled up with new writing. If you have something you think might sit well behind one of those colourful chromosomes, here’s how to contribute.

That’s a very cool project – I’m half-tempted to put something together and submit it  myself, though I have no doubt plenty of better writers will beat me to it. Maybe you’ll be one of them? [image by mtowber]

Seeing Double Triple: cloning

Welcome to the second instalment of Today’s Tomorrows here at Futurismic. I am entirely too busy lately, and I could use at least ten more hours in every day… or maybe a copy of myself. So that’s the way I stalked this month’s topic: Cloning.

As usual, I’ll start off with current news, then I’ll talk about what I expect in the future, and go on to explore the topic in science fiction. Continue reading Seeing Double Triple: cloning

The key to ending ageing?

This week’s inescapable big science story is that of Brooke Greenberg, the teenage girl whose physical and mental development has seemingly  stalled at the stage of an 11 month old infant. In addition to the lamentable tabloid freak-show component to the story, however, is the claim from a researcher that Brooke’s genetic make-up may hold the key to arresting the ageing process.

Walker thinks that Brooke is the first recorded case of what he describes as “developmental disorganization”. His hypothesis is that the cause is disruption of an as-yet unidentified gene, or genes, that hold the key to ageing by orchestrating how an organism matures to adulthood, reproduces, then gradually ages and dies.

Walker believes that Brooke lacks this “regulator” of development – first proposed in 1932 by British marine biologist, George Parker Bidder. Like Bidder, Walker believes that the regulator guides organisms through to adulthood, but also works beyond then to orchestrate ageing and, eventually, death.

It bears repeating that this is one man’s hypothesis rather than a species-wide day-pass to the fountain of youth, but let’s assume for a moment he’s right. The first ethical question here is whether Brooke should be treated as a potential source of human immortality rather than simply as an unfortunate girl in need of a lifetime of care. Personally I don’t see a problem with researching the implications of a condition alongside giving palliative care for it, as discussed in the neo-eugenics post the other day.

The second ethical question – and, to my mind, the much more important one – is whether we’re right to be chasing after human immortality as a goal. It’s a much fuzzier line; while I don’t see any problem with wanting to extend the human lifespan and eradicate the negative aspects of the physical ageing process (a matter on which I am somewhat on-side with the transhumanists), I’m not sure that we’re yet in a geopolitical state as a species where we could cope with radically extended lifespans.

Most of our modern wars revolve around resources, and resources are becoming scarcer because people already live much longer than they did a century or two ago; how much more of an issue will energy supply be in developed nations when the average life expectancy has an extra handful of decades tacked onto it? Will birth rates decline in proportion to increased lifespan, and if not, how will we cope with a population that is both expanding and greying?

Neo-eugenics – the ethics of pre-natal screening

babyThe better we get at sequencing and manipulating the genetic codes that make us who we are, the more inevitable it is that we find ourselves faced with opening the Pandora’s Box of eugenics. Indeed, you could argue we’ve already cracked the lid and peeked; this report from the European Molecular Biology Organization points out that screening unborn kids for Down’s Syndrome is a form of eugenics:

These abortions are eugenic in both intention and effect—that is, their purpose is to eliminate a genetically defective fetus and thus allow for a genetically superior child in a subsequent pregnancy. This is a harsh way of phrasing it; another way is to say that parents just want to have healthy children. Nevertheless, however it is phrased, the conclusion is starkly unavoidable: terminating the pregnancy of a genetically defective fetus is widespread. Moreover, because none of the countries mentioned above coerce parents into aborting deformed fetuses, these abortions—which number many thousands each year—are carried out at the request of the parents, or at least the mothers. This high number of so-called medical abortions shows that many people, in many parts of the world, consider the elimination of a genetically defective fetus to be morally acceptable.

There are plenty of other mutations that can be screened for as well, but the nature of the tests means they’re not done across the board:

However, such tests probably do not markedly decrease the mutational burden of a nation’s newborns. Usually, a fetus is only tested for a specific mutation when its family medical history indicates that there is a clear risk. If, as must often be the case, parents are oblivious to the fact that they are carriers of a genetic disorder, they will have no reason to undergo a prenatal diagnosis, which is both expensive and invasive. Fetuses are also not tested for de novo mutations. However, given that many—perhaps most—parents want healthy children, should all fetuses be screened for many disease-causing mutations?

To myself at least, the question’s a total no-brainer – of course they should. If science isn’t for improving the quality of life of as many people as possible, then what is it for? [via FuturePundit; image by Hammer51052]

But as we well know, not everyone would agree – and recent events have demonstrated the extreme measures people are willing to take to voice and defend that belief, despite the inherent hypocrisy of murdering someone you consider to be a murderer. Thankfully such extremists are a minority, but abortion remains an emotionally charged issue, especially where religion comes into the picture. Rational logic dictates that giving every parent the choice is the fairest compromise, but rational logic fails when one side of the debate uses an appeal to a higher authority to deny the right of choice to everyone, regardless of their belief set.

Unlike Creationism – which I’m unafraid to label as a provably delusional philosophy – the ethical borders in debates around eugenics and abortion are fuzzy, based as they are on spiritual ideas that cannot be measured and tested in the same way as the geological age of the Earth. I don’t think anyone who believes that abortion is a form of murder should be forced to have one against their will, but nor do I think that those people should be permitted to deny that choice to others, be it by legal force, intimidation or worse. Whether there is a solution that will satisfy everyone remains to be seen – but as genetic science progresses, the need to reach that compromise will become more urgent. Let’s just hope we can find it without further bloodshed.

Biotech to the stars

dendritesCentauri Dreams discusses a DNA-based self-replicating interstellar probe:

Think of a probe that gets around the payload mass problem by using molecular processes to create cameras and imaging systems not by mechanical nanotech but by inherently biological methods.

A Von Neumann self-replicating probe comes to mind, but we may not have to go to that level in our earliest iterations. The biggest challenge to our interstellar ambitions is propulsion, with the need to push a payload sufficient to conduct a science mission to speeds up to an appreciable percentage of lightspeed. The more we reduce payload size, the more feasible some missions become

This is similar to Robert L. Forward‘s starwisp concept (popularised by Charlie Stross in Accelerando).

I suspect that if and when we do get round to interstellar exploration it will involve sending small-mass packages that are capable of bootstrapping themselves to a broadcast/exploration mode using local materials on arrival in the target system.

It remains to be seen what kind of space-based molecular replicating systems become viable. Will we be able to create space-hardened bioware, or good ol’ fashioned machine phase fullerene nanotech?

[image from neurollero on flickr]